BDBM426456 ((2R,5R)-2-methyl-5-(pyrazolo[1,5- alpha]pyrazin-4-yloxy)piperidin-1-yl) (2-(pyrimidin-2-yl)thiophen-3-yl) methanone::US10526336, Example 75

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccsc1-c1ncccn1)Oc1nccn2ccnc12

InChI Key InChIKey=YVNBZCNMZNYMGL-HUUCEWRRSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 426456   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426456(((2R,5R)-2-methyl-5-(pyrazolo[1,5- alpha]pyrazin-4...)
Affinity DataIC50:  1.77E+3nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck, Sharp & Dohme

US Patent
LigandPNGBDBM426456(((2R,5R)-2-methyl-5-(pyrazolo[1,5- alpha]pyrazin-4...)
Affinity DataIC50:  20.6nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent