BDBM428786 (R or S)-5-(9-ethyl-8-(2- methylpyrimidin-5-yl)-9H- purin-6-yl)-1''- (methylsulfonyl)spiro [indoline-3,2''-pyrrolidin]-2- one::US10544147, Compound 3-19::US10544147, Compound 3-20

SMILES CCn1c(nc2c(ncnc12)-c1ccc2NC(=O)C3(CCCN3S(C)(=O)=O)c2c1)-c1cnc(C)nc1

InChI Key InChIKey=LUEHWLWEACMXEJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 428786   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM428786((R or S)-5-(9-ethyl-8-(2- methylpyrimidin-5-yl)-9H...)
Affinity DataIC50:  55nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM428786((R or S)-5-(9-ethyl-8-(2- methylpyrimidin-5-yl)-9H...)
Affinity DataIC50:  0.700nMAssay Description:The PI3-Kinase biochemical assays were developed to measure the intrinsic potency and compound dependent inhibition of the alpha, beta, delta, and ga...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent