BDBM429774 (5R)-5-[3-[4- (4-chloro-3- methoxy-5- methyl- phenyl)-1- piperidyl]-3- oxo-propyl]-5- methyl- imidazolidine- 2,4-dione::US10550100, Compound 98
SMILES COc1cc(cc(C)c1Cl)C1CCN(CC1)C(=O)CC[C@@]1(C)NC(=O)NC1=O
InChI Key InChIKey=JRFZSMAIBXKQOW-HXUWFJFHSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 429774
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos
US Patent
Galapagos
US Patent
Affinity DataIC50: 75nMAssay Description:The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For the dose res...More data for this Ligand-Target Pair
Affinity DataIC50: 12.5nMAssay Description:The basis for the assay is the cleavage of the substrate 520 MMP FRET substrate XII by human ADAMTS6.The substrate contains sequence Arg-Pro-Lys-Pro-...More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP14 (Biomol, Cat#SE-259).For the...More data for this Ligand-Target Pair
Affinity DataIC50: >100nMAssay Description:The basis for the assay is the cleavage of the substrate 390 MMP FRET Substrate I (Anaspec Cat# AS-27076) by human MMP13 (Chemicon, Cat#CC068).For th...More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Galapagos
US Patent
Galapagos
US Patent
Affinity DataIC50: 37.5nMAssay Description:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEMS INC...More data for this Ligand-Target Pair