BDBM430034 US10538528, Compound 16

SMILES COc1cc(c(F)cn1)-c1ccc(NCCN2CCCC2)c(n1)C1CCN(CC1)c1ncnc2NC(=O)C(C)c12

InChI Key InChIKey=NNEGEHDJOHHIGP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 430034   

TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430034(US10538528, Compound 16)
Affinity DataIC50:  1.90nMAssay Description:Akt1 was prepared and assays of inhibitory activity of the compound according to the present invention against Akt1 kinase activity in vitro were con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430034(US10538528, Compound 16)
Affinity DataIC50:  0.700nMAssay Description:S6K1: Inhibitory activity of the compound according to the present invention on S6K1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRyanodine receptor 1 [4317-4329]()
Taiho Pahrmaceutical

US Patent
LigandPNGBDBM430034(US10538528, Compound 16)
Affinity DataIC50:  0.800nMAssay Description:Rsk1: Inhibitory activity of the compound according to the present invention on Rsk1 kinase activity in vitro was assayed using the QSS Assist FP ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent