BDBM43502 2-furanyl-[4-(5H-pyrimido[5,4-b]indol-4-yl)-1-piperazinyl]methanone::2-furyl-[4-(5H-pyrimid[5,4-b]indol-4-yl)piperazino]methanone::MLS000078379::SMR000039794::cid_658799::furan-2-yl-[4-(5H-pyrimido[5,4-b]indol-4-yl)piperazin-1-yl]methanone

SMILES O=C(N1CCN(CC1)c1ncnc2c3ccccc3[nH]c12)c1ccco1

InChI Key InChIKey=LVBLJETUJLRUDS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 43502   

TargetSignal transducer and activator of transcription 3 [702-738,740-752](Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43502(2-furanyl-[4-(5H-pyrimido[5,4-b]indol-4-yl)-1-pipe...)
Affinity DataIC50: >5.57E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
LigandPNGBDBM43502(2-furanyl-[4-(5H-pyrimido[5,4-b]indol-4-yl)-1-pipe...)
Affinity DataIC50:  6.06E+3nMAssay Description:Inhibition of BCRP (unknown origin) expressed in dog MDCK-II cells using pheophorbide A as substrate preincubated for 20 mins followed by substrate a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM43502(2-furanyl-[4-(5H-pyrimido[5,4-b]indol-4-yl)-1-pipe...)
Affinity DataIC50:  169nMAssay Description:Inhibition of MRP1 in human NCI-H69AR cells incubated for 180 mins in presence of daunorubicin by flow cytometry analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSignal transducer and activator of transcription 1-alpha/beta(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM43502(2-furanyl-[4-(5H-pyrimido[5,4-b]indol-4-yl)-1-pipe...)
Affinity DataIC50:  1.69E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute (TSRI) Assay...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay