BDBM435721 US10570155, Compound 25III::US11332479, Compound 25III

SMILES Oc1cccc(c1)-c1nc2sccn2c1-c1ccnc(NCCNS(=O)(=O)c2ccc(F)cc2)n1

InChI Key InChIKey=YDYJBUHNTGURQT-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 435721   

TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  5.70nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  8.71E+3nMAssay Description:Inhibition of NTRK2 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  5.70nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  1nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human wild type BRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human BRAF V600E mutant using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human wild type CRAF using myelin basic protein as substrate in presence of [gamma-33P]ATP incubated for 40 mins by scintillation count...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of ABL1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  9.54E+3nMAssay Description:Inhibition of ERN1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  9.58E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  1.99E+3nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHomeodomain-interacting protein kinase 1(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  5.13E+3nMAssay Description:Inhibition of HIPK1 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of MAPK8 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition of MAPK11 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  2.01E+3nMAssay Description:Inhibition of MAPK14 (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 20(Homo sapiens (Human))
National Research Centre (Nrc)

Curated by ChEMBL
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  7.58E+3nMAssay Description:Inhibition of ZAK (unknown origin) incubated for 1 hr by qPCR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
Korea Institute of Science and Technology

US Patent
LigandPNGBDBM435721(US10570155, Compound 25III | US11332479, Compound ...)
Affinity DataIC50:  1nMAssay Description:Reaction biology kinase hotspot service (http://www.reactionbiology.com) was used to measure IC50. In a final reaction volume of 25 μL, kinase (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent