BDBM439498 US10633379, Example 36

SMILES Cc1cc(F)cc(C)c1Oc1ccc(cc1-c1cn(C)c(=O)c2[nH]c(cc12)C(=O)NC(C)(C)C)C(C)(C)O

InChI Key InChIKey=YSFIKYDQTQWEIH-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 439498   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439498(US10633379, Example 36)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human N-terminal His6 tagged BRD4 BD2 (352 to 457) residues expressed in Escherichia coli BL21(DE3) cells after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [352-457](Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM439498(US10633379, Example 36)
Affinity DataKi:  3.40nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM439498(US10633379, Example 36)
Affinity DataKi:  310nMAssay Description:Inhibition of human N-terminal His6 tagged BRD4 BD1 (57 to 168) residues expressed in Escherichia coli BL21(DE3) cells after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [57-168](Homo sapiens (Human))
Abbvie

US Patent
LigandPNGBDBM439498(US10633379, Example 36)
Affinity DataKi:  579nMAssay Description:Compound dilution series were prepared in DMSO via an approximately 3-fold serial dilution. Compound dilutions were added directly into white, low-vo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent