BDBM441837 US10647665, Example 1-23::US10851050, Example I-23

SMILES OC(=O)Cc1ccc(CNC(=O)Nc2ccc(cc2)-c2ccccc2)cc1

InChI Key InChIKey=JGINBPKDFJSKCS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 441837   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

US Patent
LigandPNGBDBM441837(US10647665, Example 1-23 | US10851050, Example I-2...)
Affinity DataIC50:  2.75E+5nMAssay Description:1. Preparation of RORgamma Buffer Solution10 mL of DTT and 100 mL buffer solution were gently mixed together and ready to use.2. Preparation of Compo...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

US Patent
LigandPNGBDBM441837(US10647665, Example 1-23 | US10851050, Example I-2...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inverse agonist activity at human RORgammat assessed as inhibition of N-terminal biotinylated co-activator SRC1 recruitment measured after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Fudan University

US Patent
LigandPNGBDBM441837(US10647665, Example 1-23 | US10851050, Example I-2...)
Affinity DataIC50:  2.75E+4nMAssay Description:The inhibitory activity of compounds on RORγ receptor was determined by fluorescence resonance energy transfer (FRET) experiments. The inhibitor...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent