BDBM444840 US10668094, Compound DcB-(cyclic)::US10668094, Compound DtxcB-(cyclic)::US11077128, Compound DcB

SMILES C[C@@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]1C[C@H](O)[C@H](OC2CCN(CC(C)O2)C2CCC2)[C@H](C)O1)O[C@H]1CC[C@@]2(C)C(CCC3C2C[C@H](O)[C@]2(C)[C@H](CC[C@]32O)C2=CC(=O)OC2)C1

InChI Key InChIKey=SBVAMPLOGURESG-GSUYKFLRSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 444840   

TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-3(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  4nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-3(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  4.30nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-2(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  5.30nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  5.40nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-2(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  6nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  8nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-2/beta-1(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  8nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  30.7nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  135nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium/potassium-transporting ATPase subunit alpha-1/beta-1(Homo sapiens (Human))
Yeda Research and Development

US Patent
LigandPNGBDBM444840(US10668094, Compound DcB-(cyclic) | US10668094, Co...)
Affinity DataKi:  135nMAssay Description:To screen for isoform selectivity of the digoxin derivatives we compared inhibition of Na,K-ATPase activity of purified detergent-soluble human isofo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent