BDBM445169 (S)-1-cyano-N-(4-(3- cyanophenyl)thiazol-2-yl)- N-methylpyrrolidine-2- carboxamide::US10669234, Example 126::US11319287, Example 126

SMILES CN(C(=O)[C@@H]1CCCN1C#N)c1nc(cs1)-c1cccc(c1)C#N

InChI Key InChIKey=LJALYPZMAKFPSM-HNNXBMFYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 445169   

TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM445169((S)-1-cyano-N-(4-(3- cyanophenyl)thiazol-2-yl)- N-...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 (μM) in 50% DMSO in a 96-well p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM445169((S)-1-cyano-N-(4-(3- cyanophenyl)thiazol-2-yl)- N-...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM445169((S)-1-cyano-N-(4-(3- cyanophenyl)thiazol-2-yl)- N-...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase isozyme L1(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM445169((S)-1-cyano-N-(4-(3- cyanophenyl)thiazol-2-yl)- N-...)
Affinity DataIC50:  550nMAssay Description:Dilution plates were prepared at 21 times the final concentration (2100 μM for a final concentration of 100 μM) in 50% DMSO in a 96-well po...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 30(Homo sapiens (Human))
Mission Therapeutics

US Patent
LigandPNGBDBM445169((S)-1-cyano-N-(4-(3- cyanophenyl)thiazol-2-yl)- N-...)
Affinity DataIC50: <100nMAssay Description:Inhibition of USP30 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed