BDBM449844 1,3-dimethyl-5-[2-tetrahydropyran-4-yl-3-[2-(trifluoromethoxy)ethyl]benzimidazol-5-yl]pyridin-2-one ::US10703740, Compound 1::US11365186, Compound 1

SMILES Cc1cc(cn(C)c1=O)-c1ccc2nc(C3CCOCC3)n(CCOC(F)(F)F)c2c1

InChI Key InChIKey=KPWWFNXRLAAREN-UHFFFAOYSA-N

Data  2 IC50  5 Kd

PDB links: 2 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 449844   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
Neomed Institute

US Patent
LigandPNGBDBM449844(1,3-dimethyl-5-[2-tetrahydropyran-4-yl-3-[2-(trifl...)
Affinity DataIC50:  140nMAssay Description:To measure activity of bromodomain inhibitors, a His-epitope tagged BRD4 BD149-170 is purchased from BPS Bioscience. BRD4 binding and inhibition is a...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Epigenetix

US Patent
LigandPNGBDBM449844(1,3-dimethyl-5-[2-tetrahydropyran-4-yl-3-[2-(trifl...)
Affinity DataIC50:  140nMAssay Description:To measure activity of bromodomain inhibitors, a His-epitope tagged BRD4 BD149-170 is purchased from BPS Bioscience. BRD4 binding and inhibition is a...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 2(Homo sapiens (Human))TBA
LigandPNGBDBM449844(1,3-dimethyl-5-[2-tetrahydropyran-4-yl-3-[2-(trifl...)
Affinity DataKd:  9nMAssay Description:Binding affinity BRD2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCREB-binding protein(Homo sapiens (Human))TBA
LigandPNGBDBM449844(1,3-dimethyl-5-[2-tetrahydropyran-4-yl-3-[2-(trifl...)
Affinity DataKd:  19nMAssay Description:Binding affinity to CBP (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Neomed Institute

US Patent
LigandPNGBDBM449844(1,3-dimethyl-5-[2-tetrahydropyran-4-yl-3-[2-(trifl...)
Affinity DataKd:  7.10nMAssay Description:Binding affinity BRD4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetHistone acetyltransferase p300(Homo sapiens (Human))TBA
LigandPNGBDBM449844(1,3-dimethyl-5-[2-tetrahydropyran-4-yl-3-[2-(trifl...)
Affinity DataKd:  31nMAssay Description:Binding affinity to EP300 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 3(Homo sapiens (Human))TBA
LigandPNGBDBM449844(1,3-dimethyl-5-[2-tetrahydropyran-4-yl-3-[2-(trifl...)
Affinity DataKd:  3.5nMAssay Description:Binding affinity BRD3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In DepthDetails PubMed