BDBM450377 1-{2,6-dichloro-4-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}-3-{[5-(trifluoromethyl)-2-pyridinyl]methyl}urea::US10676438, Example 32

SMILES O[C@H](c1cc(Cl)c(NC(=O)NCc2ccc(cn2)C(F)(F)F)c(Cl)c1)C(F)(F)F

InChI Key InChIKey=XKAKAEMIPHQYGG-CYBMUJFWSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 450377   

TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM450377(1-{2,6-dichloro-4-[(1R)-2,2,2-trifluoro-1-hydroxye...)
Affinity DataIC50: >1.00E+4nMAssay Description:Using HEK293 cell overexpressing a human ether-a-go-go-related gene (hERG), the maximum tale current of the hERG IKr current induced by redepolarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Ono Pharmaceutical

US Patent
LigandPNGBDBM450377(1-{2,6-dichloro-4-[(1R)-2,2,2-trifluoro-1-hydroxye...)
Affinity DataIC50: >1.00E+4nMAssay Description:Using HEK293 cell overexpressing a human ether-a-go-go-related gene (hERG), the maximum tale current of the hERG IKr current induced by redepolarizat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent