BDBM450730 US10676467, Compound 8c::US10676467, Compound TZ 35 104

SMILES OCc1ccc(cc1)-c1noc(n1)-c1ccc(OCCF)c(c1)C(F)(F)F

InChI Key InChIKey=MHXTXRZADPVWNK-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 450730   

TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50:  6.70nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50:  6.70nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of S1PR1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50:  6.67nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Washington University

US Patent
LigandPNGBDBM450730(US10676467, Compound 8c | US10676467, Compound TZ ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Newly synthesized compounds were first evaluated for binding potency toward S1P1 by a [32P]S1P competitive binding assay following published procedur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent