BDBM455328 US10730875, Compound 30

SMILES O=C(Nc1cn2c(cccc2n1)-c1ccc(NS(=O)(=O)C2CC2)cc1)C1CC1

InChI Key InChIKey=MXHNRBRZUMAARS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 455328   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Jn Therapeutics

US Patent
LigandPNGBDBM455328(US10730875, Compound 30)
Affinity DataIC50: <500nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN™ time-resolved fluorescence energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Jn Therapeutics

US Patent
LigandPNGBDBM455328(US10730875, Compound 30)
Affinity DataIC50:  750nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN™ time-resolved fluorescence energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Jn Therapeutics

US Patent
LigandPNGBDBM455328(US10730875, Compound 30)
Affinity DataIC50: <500nMAssay Description:To assay JAK1 inhibition, 2 μL of IL-6 diluted at 400 ng/mL (4×) in HBSS containing 0.1% BSA was added to the treated cells. The cells were then...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Jn Therapeutics

US Patent
LigandPNGBDBM455328(US10730875, Compound 30)
Affinity DataIC50: <500nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN™ time-resolved fluorescence energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Jn Therapeutics

US Patent
LigandPNGBDBM455328(US10730875, Compound 30)
Affinity DataIC50: >5.00E+3nMAssay Description:The in vitro inhibition of recombinant human JAKs was determined as follow.Compounds were tested in LANTHASCREEN™ time-resolved fluorescence energy t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent