BDBM456055 US10723709, Example 5

SMILES CN1CCN(CC1)c1nc(c(F)s1)-c1ccc(cc1)C(=O)NC(C=O)(C1CCCC1)N1CC(C#C)C2OCC(=O)C12

InChI Key InChIKey=CSNLQUVWWAGDSS-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 456055   

TargetCathepsin K(Homo sapiens (Human))
Medivir

US Patent
LigandPNGBDBM456055(US10723709, Example 5)
Affinity DataKi:  0.600nMAssay Description:The recombinant cathepsin K can be expressed in a variety of commercially available expression systems including E coli, Pichia and Baculovirus syste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProcathepsin L(Homo sapiens (Human))
Medivir

US Patent
LigandPNGBDBM456055(US10723709, Example 5)
Affinity DataKi:  1.17E+3nMAssay Description:The enzyme is commercially available human cathepsin L. The substrate is H-D-Val-Leu-Lys-AMC available from Bahcem. The assay buffer is 100 mM sodium...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin S(Homo sapiens (Human))
Medivir

US Patent
LigandPNGBDBM456055(US10723709, Example 5)
Affinity DataKi:  2.90E+3nMAssay Description:The assay uses baculovirus-expressed human cathepsin S and the boc-Val-Leu-Lys-AMC fluorescent substrate available from Bachem in a 384 well plate fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent