BDBM456278 (R)-4-ethoxy-6-(4-(((2- hydroxy-2-(4-methyl-1- oxo-1,3- dihydroisobenzofuran-5- yl)ethyl)amino)methyl)- 1H-pyrazol-1- yl)nicotinonitrile::US10723723, Example 152

SMILES CCOc1cc(ncc1C#N)-n1cc(CNC[C@H](O)c2ccc3C(=O)OCc3c2C)cn1

InChI Key InChIKey=QUTCUXPVBZRUIV-FQEVSTJZSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 456278   

TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM456278((R)-4-ethoxy-6-(4-(((2- hydroxy-2-(4-methyl-1- oxo...)
Affinity DataIC50:  6.20nMAssay Description:Solutions and reagents: Thallium flux assay was performed using FluxOR kit (F10017, Life Technologies). Loading buffer, assay buffer and stimulus buf...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent