BDBM459029 (4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl]methyl}piperazin-1-yl) [6-(trifluoromethoxy)pyridin-2-yl]methanone::US10759794, Example 67

SMILES FC(F)(F)Oc1cccc(n1)C(=O)N1CCN(Cc2c(nc3ccccn23)-c2ccc(Cl)cc2)CC1

InChI Key InChIKey=SIFMANNOUHDCIV-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 459029   

TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM459029((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...)
Affinity DataIC50:  42nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPotassium channel subfamily K member 3(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM459029((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...)
Affinity DataIC50:  7.60E+3nMAssay Description:Inhibition of human TASK-1 expressed in Xenopus laevis oocytes assessed as inhibition of channel current at +40mV holding potential by two-electrode ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetPotassium channel subfamily K member 9(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM459029((4-{[2-(4-Chlorophenyl)imidazo [1,2-a]pyridin-3-yl...)
Affinity DataIC50:  9.40nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent