BDBM463267 4-Amino-5-(3-chloro-4- hydroxyphenyl)-5- methyl-2-{8-[(4-methyl- cyclohexyl)methyl]- imidazo[1,2-a]pyrazin- 6-yl}-5,7-dihydro-6H- pyrrolo[2,3-d]pyrimidin- 6-one::US10780092, Example 120-BA::US10780092, Example 120-BB

SMILES CC1CCC(Cc2nc(cn3ccnc23)-c2nc3NC(=O)C(C)(c3c(N)n2)c2ccc(O)c(Cl)c2)CC1

InChI Key InChIKey=SSSLETLXJBTJJS-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463267   

TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463267(4-Amino-5-(3-chloro-4- hydroxyphenyl)-5- methyl-2-...)
Affinity DataKi:  3.79nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGuanylate cyclase soluble subunit alpha-1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM463267(4-Amino-5-(3-chloro-4- hydroxyphenyl)-5- methyl-2-...)
Affinity DataKi:  10.9nMAssay Description:The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent