BDBM463445 US10781182, Compound IA2-140::US11091445, Compound code IA2-140

SMILES COc1nc2ccc(OC)cc2n1CCCNC(C)=O

InChI Key InChIKey=IGBXTAHNBAVPGY-UHFFFAOYSA-N

Data  6 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 463445   

TargetMelatonin receptor type 1A(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463445(US10781182, Compound IA2-140 | US11091445, Compoun...)
Affinity DataKi:  2.20nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelatonin receptor type 1A(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463445(US10781182, Compound IA2-140 | US11091445, Compoun...)
Affinity DataKi:  2.20nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463445(US10781182, Compound IA2-140 | US11091445, Compoun...)
Affinity DataKi:  2.20nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463445(US10781182, Compound IA2-140 | US11091445, Compoun...)
Affinity DataKi:  11nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelatonin receptor type 1B(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463445(US10781182, Compound IA2-140 | US11091445, Compoun...)
Affinity DataKi:  11nMAssay Description:Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMetallothionein-2(Human)
AchÉ

US Patent
LigandPNGBDBM463445(US10781182, Compound IA2-140 | US11091445, Compoun...)
Affinity DataKi:  11nMAssay Description:The binding assay was performed in melatonergic MT1 and MT2 receptors in order to check the receptor affinity for the ligand, i.e., the ability of th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMelatonin receptor type 1A(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463445(US10781182, Compound IA2-140 | US11091445, Compoun...)
Affinity DataEC50:  1.90nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spec...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1A(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463445(US10781182, Compound IA2-140 | US11091445, Compoun...)
Affinity DataEC50:  0.233nMAssay Description:Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by Hi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMelatonin receptor type 1B(Homo sapiens (Human))
AchÉ

US Patent
LigandPNGBDBM463445(US10781182, Compound IA2-140 | US11091445, Compoun...)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed