BDBM463461 3-(4-Fluorophenyl)-2-(4-(4-(trifluoromethyl)phenyl)piperidin-1-yl)quinoxaline-6-carboxylic acid::US10781185, Example 29::US11459307, Example 29

SMILES OC(=O)c1ccc2nc(N3CCC(CC3)c3ccc(cc3)C(F)(F)F)c(nc2c1)-c1ccc(F)cc1

InChI Key InChIKey=XNQAOBKHXBGGHD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 463461   

TargetPAS domain-containing serine/threonine-protein kinase(Homo sapiens (Human))
Bioenergenix

US Patent
LigandPNGBDBM463461(3-(4-Fluorophenyl)-2-(4-(4-(trifluoromethyl)phenyl...)
Affinity DataIC50: <1.00E+3nMAssay Description:Purified hPASK from insect cells (0.02 μg) is added to a 50 μL reaction mix containing 40 mM HEPES (pH 7.0), 100 mM KCl, 5 mM MgCl2, 1 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPAS domain-containing serine/threonine-protein kinase [879-1323](Homo sapiens (Human))
Bioenergenix

US Patent
LigandPNGBDBM463461(3-(4-Fluorophenyl)-2-(4-(4-(trifluoromethyl)phenyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Purified PASK (UniProt #Q96RG2; human recombinant N-terminal GST tagged construct, residues 879-1323) from insect cells (final concentration 5 nM) is...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPAS domain-containing serine/threonine-protein kinase(Homo sapiens (Human))
Bioenergenix

US Patent
LigandPNGBDBM463461(3-(4-Fluorophenyl)-2-(4-(4-(trifluoromethyl)phenyl...)
Affinity DataIC50: <1.00E+4nMAssay Description:One assay for purified hPASK activity utilizes the Kinase-Glo Luminescent Kinase Assay (Promega), which quantifies the amount of ATP remaining in sol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPAS domain-containing serine/threonine-protein kinase(Homo sapiens (Human))
Bioenergenix

US Patent
LigandPNGBDBM463461(3-(4-Fluorophenyl)-2-(4-(4-(trifluoromethyl)phenyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Purified PASK (UniProt # Q96RG2; human recombinant N-terminal GST tagged construct, residues 879-1323) from insect cells (final concentration 5 nM) i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent