BDBM463999 US10787435, Example 002::US11117891, Example 2::WX002

SMILES CC(C)n1cnnc1-c1cccc(n1)N1CCc2cc(C)c(cc2C1=O)-n1cnc(c1)C1CC1

InChI Key InChIKey=HUMHHOMYRXBBQR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463999   

TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM463999(US10787435, Example 002 | US11117891, Example 2 | ...)
Affinity DataIC50:  1.80nMAssay Description:The assay is done using an ADP-Glo™ Kinase Assay Kit (Promega, Catalog #V9102) according to the manufacturer's protocol with the following modifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Eli Lilly

US Patent
LigandPNGBDBM463999(US10787435, Example 002 | US11117891, Example 2 | ...)
Affinity DataIC50: <50nMAssay Description:Reagents:Base Reaction Buffer: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOCompound T...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent