BDBM464349 Preparation of 3-(4-(1H-pyrazol-4-yl)phenyl)-8-((4,4-difluorocyclohexyl)methyl)-1-(3-methoxybenzyl)-1,3,8-triazaspiro[4.5]decan-2-one::US10787450, Example 231

SMILES COc1cccc(CN2C(=O)N(CC22CCN(CC3CCC(F)(F)CC3)CC2)c2ccc(cc2)-c2cn[nH]c2)c1

InChI Key InChIKey=BBHSJBWSVZIKFI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464349   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464349(Preparation of 3-(4-(1H-pyrazol-4-yl)phenyl)-8-((4...)
Affinity DataIC50: <3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent