BDBM464352 3-(4-(1H-pyrazol-4-yl)phenyl)-1-(3-methoxybenzyl)-8-(methylsulfonyl)-1,3,8-triazaspiro[4.5]decan-2-one::US10787450, Example 234

SMILES COc1cccc(CN2C(=O)N(CC22CCN(CC2)S(C)(=O)=O)c2ccc(Br)cc2)c1

InChI Key InChIKey=UKCXKXHOZRWSMB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464352   

TargetRho-associated protein kinase 2(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464352(3-(4-(1H-pyrazol-4-yl)phenyl)-1-(3-methoxybenzyl)-...)
Affinity DataIC50: <3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent