BDBM466375 5-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- N-[(4- sulfamoylphenyl) methyl]-5-azaspiro [2.5]octane- 8-carboxamide::US10799507, Example 33

SMILES NS(=O)(=O)c1ccc(CNC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)cc1

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466375   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466375(5-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- N-[(4- sulfa...)
Affinity DataEC50:  1.90nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466375(5-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- N-[(4- sulfa...)
Affinity DataEC50:  28.9nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466375(5-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- N-[(4- sulfa...)
Affinity DataEC50:  6nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466375(5-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)- N-[(4- sulfa...)
Affinity DataEC50:  5nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent