BDBM466488 (3,3-Difluorocyclobutyl)Methyl 5-(7H-Pyrrolo[2,3-d]Pyrimidin-4-Yl)-5-Azaspiro[2.5]Octane-8-Carboxylate::US10799507, Example 153

SMILES FC1(F)CC(COC(=O)C2CCN(CC22CC2)c2ncnc3[nH]ccc23)C1

InChI Key

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466488   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466488((3,3-Difluorocyclobutyl)Methyl 5-(7H-Pyrrolo[2,3-d...)
Affinity DataEC50:  2.30nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466488((3,3-Difluorocyclobutyl)Methyl 5-(7H-Pyrrolo[2,3-d...)
Affinity DataEC50:  68nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466488((3,3-Difluorocyclobutyl)Methyl 5-(7H-Pyrrolo[2,3-d...)
Affinity DataEC50:  8.90nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Leo Pharma

US Patent
LigandPNGBDBM466488((3,3-Difluorocyclobutyl)Methyl 5-(7H-Pyrrolo[2,3-d...)
Affinity DataEC50:  3.20nMAssay Description:Human baculovirus-expressed JAK1, 2, 3 and TYK2 were purchased from Carna Biosciences, Inc. All four purified enzymes contain only the catalytic doma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent