BDBM466592 US10800757, Compound 8::US10889568, Compound 8::[7-(6-Amino-4-methoxy-pyridin-3-yl)- 4,7-diaza-spiro[2.5]oct-4-yl]-(4- methoxy-5-phenoxy-pyridin-2-yl)- methanone

SMILES COc1cc(ncc1Oc1ccccc1)C(=O)N1CCN(CC11CC1)c1cnc(N)cc1OC

InChI Key InChIKey=QTMDPULCRGIORS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 466592   

TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466592(US10800757, Compound 8 | US10889568, Compound 8 | ...)
Affinity DataIC50:  27nMAssay Description:This screening assay measures TRPC6 (transient receptor potential cation channel, subfamily C, member 6) ion channel activation via addition either o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetShort transient receptor potential channel 6(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM466592(US10800757, Compound 8 | US10889568, Compound 8 | ...)
Affinity DataIC50:  27nMAssay Description:The commercially available HEK293/TREx line (Invitrogen) was stably transfected with a TRPC6 construct and screened by conventional calcium imaging t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent