BDBM470989 US10821115, Example 100002::US10821115, Example 100135::US11224601, Example 100135

SMILES CO[C@@]1(CC(=O)N(C)C)\C=C\C[C@H](C)[C@@H](C)S(=O)(=O)NC(=O)c2ccc3OC[C@]4(CCCc5cc(Cl)ccc45)CN(C[C@@H]4CC[C@@H]14)c3c2

InChI Key InChIKey=CJGXYTWLEUYKAL-JGALEJMMSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 470989   

TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM470989(US10821115, Example 100002 | US10821115, Example 1...)
Affinity DataKi:  0.00600nMAssay Description:Inhibition of recombinant His6-tagged human MCL1 (171 to 327 residues) expressed in Escherichia coli and biotinylated Bim BH3 peptide interaction usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM470989(US10821115, Example 100002 | US10821115, Example 1...)
Affinity DataIC50:  0.173nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM470989(US10821115, Example 100002 | US10821115, Example 1...)
Affinity DataIC50:  0.173nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM470989(US10821115, Example 100002 | US10821115, Example 1...)
Affinity DataIC50:  0.0710nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM470989(US10821115, Example 100002 | US10821115, Example 1...)
Affinity DataIC50:  0.0710nMAssay Description:The inhibition of the Mcl-1/Bim interaction was measured using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The recombinan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent