BDBM471739 US10828290, Example 22 (Diastereoisomer 2)

SMILES N[C@H]1CCCN(C1)c1c2CCC(O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F

InChI Key InChIKey=SYKQOKZJNJIFQW-SZQRVLIRSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 471739   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM471739(US10828290, Example 22 (Diastereoisomer 2))
Affinity DataIC50: <100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM471739(US10828290, Example 22 (Diastereoisomer 2))
Affinity DataIC50: <100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM471739(US10828290, Example 22 (Diastereoisomer 2))
Affinity DataIC50: <100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent