BDBM473808 3-Cyclopropyl-4-(7-oxo- 4,5,6,7-tetrahydro- benzoimidazol-1-yl)- benzonitrile::US10858342, Compound C-AAK

SMILES O=C1CCCc2ncn(c12)-c1ccc(cc1C1CC1)C#N

InChI Key InChIKey=AXEKJUQTRBMZPP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473808   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473808(3-Cyclopropyl-4-(7-oxo- 4,5,6,7-tetrahydro- benzoi...)
Affinity DataIC50:  1.70E+7nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473808(3-Cyclopropyl-4-(7-oxo- 4,5,6,7-tetrahydro- benzoi...)
Affinity DataIC50:  34nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent