BDBM473818 2-Methyl-4-(7-oxospiro[4,6- dihydrobenzimidazole-5,1'- cyclobutan]-1- yl)benzonitrile::US10858342, Compound C-AAU

SMILES Cc1cc(ccc1C#N)-n1cnc2CC3(CCC3)CC(=O)c12

InChI Key InChIKey=LRTYGFAHILJKQJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473818   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473818(2-Methyl-4-(7-oxospiro[4,6- dihydrobenzimidazole-5...)
Affinity DataIC50:  5.10E+4nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473818(2-Methyl-4-(7-oxospiro[4,6- dihydrobenzimidazole-5...)
Affinity DataIC50:  10nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent