BDBM473950 4-(5,5-Dimethyl-7-oxo- 4,5,6,7-tetrahydro- benzoimidazol-1-yl)- cyclohexanecarbonitrile::US10858342, Compound C-ADL

SMILES CC1(C)Cc2ncn([C@@H]3CC[C@@H](CC3)C#N)c2C(=O)C1

InChI Key InChIKey=HBDKDINCOYQTKK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 473950   

TargetCytochrome P450 11B1, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473950(4-(5,5-Dimethyl-7-oxo- 4,5,6,7-tetrahydro- benzoim...)
Affinity DataIC50:  7.90E+6nMAssay Description:Assays are performed as for aldosterone synthase except for the use of 150 units of CYP11B1, 11-deoxycortisol as substrate and cortisol measured as p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCytochrome P450 11B2, mitochondrial(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM473950(4-(5,5-Dimethyl-7-oxo- 4,5,6,7-tetrahydro- benzoim...)
Affinity DataIC50:  22nMAssay Description:Assays are performed in 96-well format in a final volume of 60 microL/well, containing 100 mM potassium phosphate, pH 7.4, 1% (v/v) DMSO, and additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent