BDBM474107 Pazopanib metabolite M27::US10858364, Compound M27

SMILES Cc1n(C)nc2cc(Nc3ccnc(Nc4ccc(C)c(c4)S(N)(=O)=O)n3)ccc12

InChI Key InChIKey=XWOGXAVHJKKNPO-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 474107   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474107(Pazopanib metabolite M27 | US10858364, Compound M2...)
Affinity DataKi:  188nMAssay Description:Inhibitory activity on BTK wild type (BTK-WT) and BTK Cys481Ser mutant (BTK-C481S) was measured using the LanthaScreen assay technology from ThermoFi...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Acerta Pharma

US Patent
LigandPNGBDBM474107(Pazopanib metabolite M27 | US10858364, Compound M2...)
Affinity DataIC50:  39nMAssay Description:Ramos B cells (ATCC, cat no. CRL-1923) were plated in 24-wells culture plates at 2×106 cells per well in a total volume of 900 μL DMEMF12+10% FB...More data for this Ligand-Target Pair
In DepthDetails US Patent