BDBM474122 6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 15::US10912773, Example 15::US11472810, Example 15

SMILES Fc1cccc(Cn2c(Br)cn3c(ncc3c2=O)C2CCOCC2)c1

InChI Key InChIKey=JVYBBFBHTBCHNY-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474122   

LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  58nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  115nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  58nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  115nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  15nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  58nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  115nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  58nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  115nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474122(6-Bromo-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  15nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent