BDBM474143 7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropyl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 33::US10912773, Example 33::US11472810, Example 33

SMILES Cc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1(C)CC1

InChI Key InChIKey=VCCNMXVKDHUXGT-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474143   

LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  94nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  52nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  7nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  94nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  52nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  94nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  52nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  7nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  94nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  52nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474143(7-(3-fluorobenzyl)-6-methyl-3-(1- methylcyclopropy...)
Affinity DataIC50:  7nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent