BDBM474161 7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imidazo[1,5- a]pyrazin-8(7H)-one::US10858362, Example 43::US10912773, Example 43::US11472810, Example 43

SMILES CCc1cn2c(ncc2c(=O)n1Cc1ccccc1)C1CCOCC1

InChI Key InChIKey=LEQLMZLBAGAUDL-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474161   

LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  105nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  32nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  9nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  105nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  32nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  9nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  105nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  32nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  9nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  105nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  32nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474161(7-benzyl-6-ethyl-3-(tetrahydro- 2H-pyran-4-yl)imid...)
Affinity DataIC50:  9nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent