BDBM474171 6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 54::US10912773, Example 54::US11472810, Example 54

SMILES CCc1cn2c(ncc2c(=O)n1Cc1cccc(F)c1)C1CCOCC1

InChI Key InChIKey=AFONMYZRPMFJAB-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474171   

LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  62nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  53nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  62nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  53nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  12nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  62nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  53nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  62nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  53nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474171(6-ethyl-7-(3-fluorobenzyl)-3- (tetrahydro-2H-pyran...)
Affinity DataIC50:  12nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent