BDBM474185 6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one::US10858362, Example 66--cis::US10858362, Example 66--trans

SMILES CC1CCC(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)CC1

InChI Key InChIKey=OUZGHMLKYZAFHY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 474185   

LigandPNGBDBM474185(6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3...)
Affinity DataIC50:  35nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474185(6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3...)
Affinity DataIC50:  11nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474185(6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3...)
Affinity DataIC50:  4nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474185(6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3...)
Affinity DataIC50:  7nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474185(6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3...)
Affinity DataIC50:  6nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474185(6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3...)
Affinity DataIC50:  46nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent