BDBM474197 3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1,5-a]pyrazin- 8(7H)-one::US10858362, Example 77::US10912773, Example 77::US11472810, Example 77

SMILES COc1ccc(Cn2c(C)cn3c(ncc3c2=O)C(C)C)cc1

InChI Key InChIKey=RVHZRSIRMVWVKL-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 474197   

LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  7nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  7nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  20nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  7nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  13nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzym1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM474197(3-isopropyl-7-(4-methoxybenzyl)- 6-methylimidazo[1...)
Affinity DataIC50:  20nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays was performed in 60 μL samples containing a fixed amount of the PDE1 enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent