BDBM474234 5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-methoxyphenyl)-[1,2,4]triazolo[1,5-c]pyrimidin- 8-yl)-1-methylpyridin-2(1H)-one::US10858365, Compound 61::US11629147, Cmpd. 61

SMILES COc1ccc(cc1)-c1nc(N)n2nc(Cc3ncccc3F)nc2c1-c1ccc(=O)n(C)c1

InChI Key InChIKey=PHWLGGRFNGIWGN-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 474234   

TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  4.20nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  1.70nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  28nMAssay Description:The compounds at different concentrations were incubate with hA1 membrane (from PerkinElmer) and [3H]-8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  1.70nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Mus musculus)
TBA

US Patent
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  42nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  25nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  4.20nMAssay Description:Binding affinity and specificities of the compounds against different subtype of human adenosine receptors (hA1, hA2A, hA2B and hA3) were characteriz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2b(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM474234(5-(5-amino-2-((3-fluoropyridin-2-yl)methyl)-7- (4-...)
Affinity DataIC50:  122nMAssay Description:hADORA1/CHO (hA1 expressing) cells (Genscript) were plated at 1×104 cells/well into 384-well polystyrene plates one day before starting the experimen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent