BDBM474369 (S)-6-benzhydryl-11-hydroxy-3- (hydroxymethyl)-5,6-dihydro-10H- imidazo[1,2-a]pyrido[2,1-c]pyrazin-10-one::US10858366, Example 54::US11453677, Example 54

SMILES OCc1cnc2-c3c(O)c(=O)ccn3[C@H](Cn12)C(c1ccccc1)c1ccccc1

InChI Key InChIKey=HMADPEJNCUJIKD-LJQANCHMSA-N

Data  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 474369   

TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474369((S)-6-benzhydryl-11-hydroxy-3- (hydroxymethyl)-5,6...)
Affinity DataIC50:  100nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuraminidase(Influenza A virus (strain A/Wilson-Smith/1933 H1N1...)
Novartis

US Patent
LigandPNGBDBM474369((S)-6-benzhydryl-11-hydroxy-3- (hydroxymethyl)-5,6...)
Affinity DataEC50:  2.60E+3nMAssay Description:For influenza NA assays, MDCK cells were plated in Phenol Red-free DMEM (Gibco) supplemented with 2 mM L-Glutamine, 1% sodium pyruvate (Cellgro, Mana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPolymerase acidic protein()
Novartis

US Patent
LigandPNGBDBM474369((S)-6-benzhydryl-11-hydroxy-3- (hydroxymethyl)-5,6...)
Affinity DataIC50:  100nMAssay Description:Compounds were dissolved and serially diluted in 100% DMSO then 0.5 μl was transferred to 384-well plates. 50 nM truncated Influenza A/victoria/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuraminidase()
Novartis

US Patent
LigandPNGBDBM474369((S)-6-benzhydryl-11-hydroxy-3- (hydroxymethyl)-5,6...)
Affinity DataEC50:  1.60E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeuraminidase(Influenza A virus (strain A/Memphis/1/1971 H3N2))
Novartis

US Patent
LigandPNGBDBM474369((S)-6-benzhydryl-11-hydroxy-3- (hydroxymethyl)-5,6...)
Affinity DataEC50:  4.60E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent