BDBM475669 N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)-3′-oxo-2′,3′-dihydro-1′H-spiro [cyclopropane-1,4′-[2,7]naphthyridin]-6′-yl]amino}-4-morpholin-4-ylphenyl)acrylamide::US10851105, Example 10

SMILES COc1cc(OC)c(F)c(N2Cc3cnc(Nc4cc(ccc4NC(=O)C=C)N4CCOCC4)cc3C3(CC3)C2=O)c1F

InChI Key InChIKey=KCQJQCFGYUCPSJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 475669   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM475669(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Affinity DataIC50:  115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM475669(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM475669(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Affinity DataIC50:  115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM475669(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Affinity DataIC50: <10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM475669(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM475669(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Affinity DataIC50: >200nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM475669(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Affinity DataIC50:  115nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM475669(N-(2-{[2′-(2,6-difluoro-3,5-dimethoxyphenyl)...)
Affinity DataIC50: <10nMAssay Description:The inhibitor potency of the exemplified compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent