BDBM478330 (S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4-(diethylamino)but-2-enoyl)- 1,2,3,6-tetrahydropyridin-4-yl)phenyl)propanamide::US10894786, Comp. No 14

SMILES C[C@H](C(=O)Nc1cc([nH]n1)C1CC1)c1ccc(cc1)C1=CCN(CC1)C(=O)\C=C\CBr

InChI Key

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 478330   

TargetCyclin-dependent kinase 12(Homo sapiens)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478330((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Affinity DataKd: <25nMAssay Description:Kinase-tagged T7 phage strains were grown in parallel in 24-well blocks in an E. coli host derived from the BL21 strain. E. coli were grown to log-ph...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 13(Homo sapiens (Human))
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478330((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Affinity DataIC50:  72nMAssay Description:LanthaScreen Eu Kinase Binding Assays are based on the binding and displacement of Alexa Fluor 647-labeled, ATP-competitive kinase inhibitor scaffold...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 12(Homo sapiens)
Aurigene Discovery Technologies

US Patent
LigandPNGBDBM478330((S,E)-N-(5-cyclopropyl-1H-pyrazol-3-yl)-2-(4-(1-(4...)
Affinity DataIC50:  895nMAssay Description:The inhibitory activity of the test compounds was assessed by the LANCE TR-FRET assay, which detects the ATP-dependent phosphorylation of an ULight-4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent