BDBM479345 (3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5]decan-8-yl)-6-(((6aS,8S)-8-((oxetan-3- ylmethoxy)methyl)-6a,7,8,9-tetrahydro-6H-pyrido[3,2- b]pyrrolo[1,2-d][1,4]oxazin-4-yl)thio)pyrazin- 2-yl)methanol::US10894797, Compound 34::US11034705, Compound 34::US11518772, Compound 34
SMILES C[C@@H]1OCC2(CCN(CC2)c2ncc(Sc3ccnc4N5C[C@@H](COCC6COC6)C[C@H]5COc34)nc2CO)[C@@H]1N
InChI Key InChIKey=WRYBCDHGKKPMKW-MBEBEXRASA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 479345
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics
US Patent
Nikang Therapeutics
US Patent
Affinity DataIC50: 6.20nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics
US Patent
Nikang Therapeutics
US Patent
Affinity DataIC50: 6.20nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair