BDBM479354 (3S,4S)-8-(5-(((6aS,8S)-8-(methoxymethyl)-6a,7,8,9- tetrahydro-6H-pyrido[3,2-b]pyrrolo[1,2-d][1,4]oxazin- 4-yl)thio)pyrazin-2-yl)-3-methyl-2-oxa-8- azaspiro[4.5]decan-4-amine::US10894797, Compound 43::US11034705, Compound 43::US11518772, Compound 43

SMILES COC[C@H]1C[C@H]2COc3c(Sc4cnc(cn4)N4CCC5(CO[C@@H](C)[C@H]5N)CC4)ccnc3N2C1

InChI Key InChIKey=WFRALCQQPKDCIU-DWKCODDLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 479354   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479354((3S,4S)-8-(5-(((6aS,8S)-8-(methoxymethyl)-6a,7,8,9...)
Affinity DataIC50:  4.5nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479354((3S,4S)-8-(5-(((6aS,8S)-8-(methoxymethyl)-6a,7,8,9...)
Affinity DataIC50:  4.5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479354((3S,4S)-8-(5-(((6aS,8S)-8-(methoxymethyl)-6a,7,8,9...)
Affinity DataIC50:  4.5nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent