BDBM479357 (S)-1'-(5-(((6aS,8S)-8-((methoxy- methoxy)methyl)-6a,7,8,9- tetrahydro-6H-pyrido[3,2-b]pyrrolo[1,2-d][1,4]oxazin- 4-yl)thio)pyrazin-2-yl)-5,7-dihydrospiro[cyclo- penta[b]pyridine-6,4'-piperidin]-5-amine::US10894797, Compound 46::US11034705, Compound 46::US11518772, Compound 46

SMILES COCOC[C@H]1C[C@H]2COc3c(Sc4cnc(cn4)N4CCC5(Cc6ncccc6[C@H]5N)CC4)ccnc3N2C1

InChI Key InChIKey=PAKOJENWJZRWER-OWOAZTCBSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 479357   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479357((S)-1'-(5-(((6aS,8S)-8-((methoxy- methoxy)methyl)-...)
Affinity DataIC50:  3.90nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479357((S)-1'-(5-(((6aS,8S)-8-((methoxy- methoxy)methyl)-...)
Affinity DataIC50:  3.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSH2B adapter protein 2(Human)
Nikang Therapeutics

US Patent
LigandPNGBDBM479357((S)-1'-(5-(((6aS,8S)-8-((methoxy- methoxy)methyl)-...)
Affinity DataIC50:  3.90nMAssay Description:The phosphatase reactions were carried out at room temperature in 384-well black polystyrene plates (Greiner Bio-One, Cat #784076) using assay buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent