BDBM479497 ML300-based SC inhibitor 36
SMILES Clc1cccc(CN(C(=O)Cn2nnc3ccccc23)c2ccc(cc2)-c2cn[nH]c2)c1
InChI Key InChIKey=JNKQPWXEHPYJAU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 479497
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Cleveland Clinic
Cleveland Clinic
Affinity DataIC50: 334nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.31E+3nMAssay Description:Confluent monolayers of Vero E6 ACE2 cells in 12-well plates were washed once with DMEM and infected with approximately 50 plaque forming units (PFUs...More data for this Ligand-Target Pair
Affinity DataEC50: 1.98E+3nMAssay Description:Briefly, Vero E6 ACE2 cells were cultured in 96-well flat-bottom plates at a density of 2 × 104 cells per well. Following infection of the cells with...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:The protease activity and subsequent 10-point IC50 curves were spectroscopically determined using a scaled down, end point assay adapted from a previ...More data for this Ligand-Target Pair