BDBM481946 US10913753, Compound I-13::US20230365583, Compound 22

SMILES Cc1ccc2c(N)c(sc2n1)C(=O)NCCc1ccc(cc1)C1CCNCC1

InChI Key InChIKey=CRYLYJCGHZGFEU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 481946   

TargetUbiquitin carboxyl-terminal hydrolase 28(Homo sapiens)
Valo Early Discovery

US Patent
LigandPNGBDBM481946(US10913753, Compound I-13 | US20230365583, Compoun...)
Affinity DataIC50: <200nMAssay Description:USP28: The assay was performed in a final volume of 20 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 28(Homo sapiens)
Valo Early Discovery

US Patent
LigandPNGBDBM481946(US10913753, Compound I-13 | US20230365583, Compoun...)
Affinity DataIC50: <1.00E+3nMAssay Description:USP28 (at 1 nM) was pre-incubated with different concentrations of inhibitors or DMSO as a control in 50 mM Tris pH 8, 50 mM NaCl, 0.002% Tween-20, 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetUbiquitin carboxyl-terminal hydrolase 25(Homo sapiens)
Valo Early Discovery

US Patent
LigandPNGBDBM481946(US10913753, Compound I-13 | US20230365583, Compoun...)
Affinity DataIC50:  1.10E+3nMAssay Description:USP25: The assay was performed in a final volume of 9 uL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HC1, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent