BDBM4831 1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrido[2,3-d]pyrimidin-7-yl}-3-tert-butylurea::CHEMBL49658::PD089828 analog 12

SMILES CC(C)(C)NC(=O)Nc1nc2nc(N)ncc2cc1-c1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=YRATUKRSRQKZSM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 4831   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4831(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)
Affinity DataIC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4831(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)
Affinity DataIC50: >5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4831(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory activity against platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM4831(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibitory concentration of compound against mouse Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM4831(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM4831(1-{2-amino-6-[3,5-bis(trifluoromethyl)phenyl]pyrid...)
Affinity DataIC50: >5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labeled ATP to the poly (E: Y) subs...More data for this Ligand-Target Pair
In DepthDetails Article