BDBM483551 N-((S)-4-fluorobicyclo[4.2.0]octa- 1(6),2,4-trien-7-yl)-N''-hydroxy-4-((3-(S- methylsulfonimidoyl)propyl)amino)- 1,2,5-oxadiazole-3-carboximidamide (chiral, isomer 1)::US10927086, Example 24::US10927086, Example 25

SMILES CS(=N)(=O)CCCNc1nonc1\C(N[C@H]1Cc2ccc(F)cc12)=N\O

InChI Key InChIKey=CSHCVFCVSSZIDR-ZPVYTRKOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483551   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483551(N-((S)-4-fluorobicyclo[4.2.0]octa- 1(6),2,4-trien-...)
Affinity DataIC50:  31.2nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483551(N-((S)-4-fluorobicyclo[4.2.0]octa- 1(6),2,4-trien-...)
Affinity DataIC50:  35.4nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent