BDBM483603 N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-yl]-N''-hydroxy-4-({cis-3-[(S- methylsulfonimidoyl)amino]cyclobutyl} oxy)-1,2,5-oxadiazole-3-carboximidamide (isomer 1)::US10927086, Example 61::US10927086, Example 62

SMILES CS(=N)(=O)N[C@H]1C[C@H](C1)Oc1nonc1\C(N[C@@H]1Cc2ccc(F)cc12)=N/O

InChI Key InChIKey=IBFPZVXJMRQATR-JLTZDMQQSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483603   

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483603(N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-...)
Affinity DataIC50:  146nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483603(N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-...)
Affinity DataIC50:  81.6nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent